The subject of the study in the article is the conceptual basis of construction of the target model of interaction between university and region. Hence, the topic of the article is formulated as: "the Target model of strategic interaction between the University and the region in the field of education". The objective is to design a target model of this interaction. Methods of study are the following: comparative analysis, instructional design, and benchmarking as a methodology of quality control of the interaction. As a result the definition of five main blocks of issues that determine the quality and effectiveness of pre-school, General and additional education at the university were contributed. The research results can be used in the design of teacher education in the universities of Russia. As a conclusion, it should be stated that the allocation of basic blocks between the university and the region would allow formulating the detailed conceptual and structural essence of the target model of interaction.