Objective: The aim of this study was to compare and evaluate the efficacy of different concentrations of dextrose prolotherapy for the treatment of TMJ hypermobility.Patients and methods: A prospective, randomized clinical trial

included patients with subluxation or dislocation was performed. The study comprised 30 patients. Patients were randomly divided into three equal sized groups treated with 10%, 20% and % 30 dextrose solutions respectively. Patients in all groups received injections into four different areas of each TMJ in four sessions at monthly intervals. VAS of TMJ pain, maximum mouth opening (MMO), clicking and frequency of luxations were recorded preoperatively and postoperatively after 1 month of last injection. The collected data were then statistically analyzed.

Results: Each group showed postoperatively significant improvement in TMJ pain, significant decrease in both MMO and clicking sound. Besides that, TMJ locking was not observed in any patient during the follow-up period. There were no statistically significant differences throughout the study intervals between the groups.

Conclusion: All concentrations of dextrose used as a proliferant were efficient in improvement of clinical symptoms related to painful TMJ hypermobility. There is no superiority of any concentration of dextrose over the others in prolotherapy.