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The purposes of this research were to study and compare knowledge before and after teaching and evaluate learning standard of nursing care of persons with mental health problems. The sample were 102 nursing undergraduate students at 3 in Mahasarakham nursing college, acquired by purposive sampling. The instruments used in this research were manual of teaching manual, knowledge test and evaluation form learning standard of nursing care of persons with mental health problems. The statistics used to percentage, mean, standard deviation and hypothesis testing t-test. The results revealed that after teaching, they had the knowledge higher than before teaching at the level of statistical significance .05, and learning standard in nursing care of persons with mental health problems was the most appropriate level, according on higher education qualification framework of Thailand