The purpose of this study is to explore the learning effect related to different teaching methods (computer assisted instruction and 5E learning cycle model) on basic astronomy subjects of preservice teachers. In this research the pretest-posttest experimental design was used. The working group consists a total of 100 preservice teachers who were studying different departments (50 Classroom Education, 50 Science Education) of Erciyes University in the fall semester 2016-2017 academic year. Astronomy Knowledge Test which was developed by Taşcan (2013) was used for data collection tool. For the analysis of the data; the t-test, two-way ANOVA and the descriptive statistics were conducted and the findings were interpreted with respect to each research question. The significance level was taken as. 05 for the comparisons. Two-way ANOVA results revealed that, the main effect for teaching method and program type interaction were not significant. Suggestions have been developed in the direction of the obtained results.