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This study aims is to investigate the use and effect of the Modified Frayer Model in enriching science vocabulary of Senior High School students. The design of this study is a randomized pretest-posttest control group design. The sample of this study is 60 Senior High School students of Quezon City Polytechnic University (QCPU). In both control (n=30) and experimental (n=30) groups, lessons in Earth Science were presented. Modified Frayer Model was used as instructional material in the experimental group. Independent sample t-test result showed that there is no statistically significant difference before the treatment. Paired sample t-test showed statistically significant difference between pretest and posttest scores for both control and experimental group. When posttest scores were compared, results revealed a statistically significant difference between the two groups. As conclusion, the use of the Modified Frayer Model in teaching science resulted in a significant improvement in science vocabulary of students.