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It is not easy to learn medical knowledge. How to help medical students to learn using efficient learning aids is an issue many teachers would like to resolve. This study integrated web pages and mobile devices into the teaching materials through "The Cloud Classroom of The Skeletal System" to improve interactions in learning. By combining a multi-media medical interactive learning platform, using the concept of groups and games as aids for learning and communication, the diversified and interactive method can help increase participants’ interest in learning so that their learning effects can be improved by doing exploration on their own.